Abstract: Objective To explore the mechanism and effect of isoniazid preventive therapy for among eligible HIV/AIDS in compulsory isolation detoxification center. Methods A compulsory isolation detoxification center in Ziyang city of Sichuan province was selected as the research field via a typical survey method. We established me-chanism of communication, coordination and technology guarantee between CDC and compulsory isolation detoxification hospital, strengthened training and health promotion, and we carried out TB screening to 553 HIV/AIDS patients under the management of the detoxification hospital. Meanwhile, they were administered questionnaires survey, X-ray, sputum smear, liver and kidney function and blood tests. After ruling out the active TB, 305 HIV/AIDS patients with normal liver and kidney function and consented to the preventive therapy received the isoniazid directly observed preventive therapy for 6 months, and were followed in the 1st, 2nd,4th,6th month of treatment and 6th and 12th month after treatment completion. The provincial expert group was responsible for quality control with all the abnormal chest X-ray, sputum smear results review and follow-up work supervision. Results There were a total of 553 HIV/AIDS patients and 23 cases were confirmed active TB patients, with the detection rate of 4.2%（23/553）;43 cases （7.8%,43/553）had abnormal liver function; 89 cases（16.1%,89/553）would soon end the compulsory detoxification;93 cases（23.4%,93/398）did not sign the consent form among those 398 cases who eligible for the isoniazid therapy;305 cases（76.6%,305/398）were given directly observed isoniazid preventive therapy, 297 completed six months of therapy with good medication compliance, treatment completion rate of 97.4%(297/305). Eight quited due to adverse reactions due to adverse reaction, the adverse reaction rate was 2.6%(8/305).None TB patients occurred during the 12-months follow-up after treatment completion. Conclusion Compulsory isolation detoxification center is an important place to carry out INH preventive therapy for among eligible HIV/AIDS, and the experience deserved extension.

Key words: Tuberculosis, pulmonary/drug therapy, HIV infections, Acquired immunodeficiency syndrome, Treatment outcome